Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function

Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function

Both the history of obesity and weight loss may change how menopause affects metabolic health. The purpose was to determine whether obesity and/or weight loss status alters energy balance (EB) and subsequent weight gain after the loss of ovarian function. Female lean and obese Wistar rats were randomized to 15% weight loss (WL) or ad libitum fed controls (CON). After the weight loss period, WL ...

Does weight gain lead to weight loss?

Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss.

Weight loss is accompanied by several metabolic adaptations that work together to promote rapid, efficient regain. We employed a rodent model of regain to examine the effects of a regular bout of treadmill exercise on these adaptations. Obesity was induced in obesity-prone rats with 16 wk of high-fat feeding and limited physical activity. Obese rats were then weight reduced (approximately 14% o...

Weight Loss After Stroke

Background and Purpose—Data on the prevalence and indicators of weight loss in population-based groups of stroke survivors are scarce. We aimed to find the predictors and indicators of weight loss 3 kg as a possible marker of malnutrition after stroke. Methods—We registered weight at baseline, after 4 months, and 1 year later in 305 survivors from a population-based cohort of first-ever stroke ...

Recruitment and Retention for a Weight Loss Maintenance Trial Involving Weight Loss Prior to Randomization

OBJECTIVE A weight loss maintenance trial involving weight loss prior to randomization is challenging to implement due to the potential for dropout and insufficient weight loss. We examined rates and correlates of non-initiation, dropout, and insufficient weight loss during a weight loss maintenance trial. METHODS The MAINTAIN trial involved a 16-week weight loss program followed by randomiza...